Mitochondrial Peptides That Aim to Delay Aging

How do mitochondria work?

Most of the energy required to drive metabolic activities inside a cell is produced by mitochondria, membrane-bound cell organelles (mitochondrion, singular). The mitochondria create chemical energy stored in a tiny molecule called adenosine triphosphate (ATP).

When unstained, mitochondria (typically ranging in size from 0.75 to 3 micrometers) are too tiny to be seen by the naked eye under a microscope.

They contain two membranes, an outer and an inner one, which sets them apart from most other organelles (cellular mini-organs). Each membrane plays many roles. Various parts of mitochondria serve different functions.

The number of mitochondria in a cell kind might vary considerably. Mature red blood cells, for example, contain zero mitochondria, but liver cells might have over 2,000. More mitochondria are present in cells that need a lot of power. Mitochondria consume around 40% of the cytoplasm in cardiac muscle cells.

Despite their often depicted oval form, mitochondria continually fission and fuse (fusion). As a result, these organelles are connected in dynamic webs. The sperm cell’s spiraling mitochondria, which power the tail’s movement, are located in the cell’s midsection. Buy peptides if you are a licensed professional.

What happens to our mitochondria with aging? 

The reduction in mitochondrial function that occurs with aging is linked to alterations in mitochondria. The accumulation of mutations and oxidative damage generated by reactive oxygen species reduces mitochondrial DNA’s volume, integrity, and functioning as organisms age (ROS).

Several mitochondrial functions decline with age, including oxidative capability, oxidative phosphorylation, ATP synthesis, reactive oxygen species (ROS) formation, and antioxidant defense. Mitophagy, an autophagy process that eliminates malfunctioning mitochondria, is inhibited due to age-related changes in mitochondrial dynamics, reducing mitochondrial biogenesis.

Changes in mitochondrial quality control that occur as a result of aging further compromise mitochondrial function. In aged tissues, increasing mitochondria-mediated apoptosis leads to an increase in the proportion of apoptotic cells. However, applying peptides and techniques such as calorie restriction and frequent physical exercise may postpone mitochondrial aging and decrease the age-related phenotype.

What You Need to Know

A person’s overall health may be severely impacted by mitochondrial illness. Mitochondrial illnesses are associated with a wide range of health issues, including but not limited to chronic fatigue, impaired hearing and seeing weakness, metabolic strokes, seizures, cardiomyopathy, arrhythmias, developmental or cognitive disabilities, liver and gastrointestinal disorders, and many others. Diseases including Alzheimer’s, muscular dystrophy, Lou Gehrig’s, diabetes, and cancer may all be influenced by secondary mitochondrial dysfunction caused by these disorders.

SS-31

SS-31, what is it?

The SS-31 family of short peptides exclusively localizes to the inner mitochondrial membrane and has inherent protective abilities. SS-31 (or MTP-131) is a mitochondria-targeting peptide soluble in water and inhibits mitochondrial reactive oxygen species generation and cytochrome c release. This peptide has been found to quickly renew oxidative phosphorylation in old animals, reverse the progression of diabetes, and reduce the severity of pulmonary arterial hypertension and heart failure caused by transverse aortic constriction.

What are the benefits of SS-31?

As a new mitochondrial-target therapeutic peptide, SS-31 can pass the blood-brain barrier (BBB) and bind to the inner mitochondrial membrane (IMM). To put it simply, mitochondria are essential to cellular metabolism. The mitochondrial malfunction has been linked to various disorders due to its impact on cellular processes. Mitochondrial failure leads to reduced ATP generation and inadequate energy to sustain cell activity, followed by cell damage and even cell death.

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